Dimethomorph (CAS No.: 110488-70-5 )

  Generic: Dimethomorph
Chem name: E,Z-4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl) acryloyl] morpholine
CAS No: 110488-70-5
Molecular formula: C21H22ClNO4
Molecular weight: 387.9
P hysical & Chemical Character

Appearance Tech. pale white crystal solid. M.p.127-148℃; (E)-isomer 135.7-137.5℃; (Z)-isomer 169.2-170.2℃. V.p.(E)-isomer 9.7×10-4mPa; (Z)-isomer 1.0×10-3mPa(both 25℃). Solubility in water ＜50mg/l(20-23℃). In acetone 88(E), 15(Z); cyclohexanone 27(Z); dichloromethane 315(Z); dimethylformamide 272(E); hexane 0.04(E), 0.02(Z); methanol 7(Z), toluene 7(Z) (all in g/l, 20-23℃). Stability Hydrolytically and thermally stable under normal conditions. Stable for ＞5years in the dark. The (E)-and (Z)-isomers are interconverted in sunlight.
  
Toxicity

Oral Acute oral LD50 for male rats 4300, female rats 3500, male mice＞5000, female mice 3700mg/kg b.w.. Skin and eye Acute percutaneous LD50 for rats ＞5000mg/kg b.w.; not irritant to skin or eyes of rabbit. Not a skin sensitizer (guinea pigs). Inhalation LC50(4h) for rats＞4.2mg/l air. Noel(2y): for rats 200mg/kg diet; (1y) for gogs 450mg/kg diet. Toxicity class WHO (a.i.) Ⅲ.
  
Application

Local systemic fungicide with good protectant, curative and antisporulant activity. Only the (Z)-isomer is intrinsically activity, because of rapid interconversion of isomers in the light, it has no advantage over the (E)-isomer in practice. Fungicide effective against Oomycetes, espically Peronosporaceae and Phytophthor spp. (but no pythium spp.) in vine, potatoes, tomatoes and other crops. Used in combination with contace fungicide( dithianon, mancozeb, fentin hydroxide or copper compounds).